Figure) Long-term cultivated spheroid cells
of corneal limbal epithelial niche.
Our goal is to conduct a wide range of clinically applicable research. We continue to encounter a variety of diseases related to stem cell damage in the limbal region, resulting in deterioration of eyesight. For such patients, we are already performing transplants of cultivated epithelial sheets containing corneal epithelial stem cell. However, in order to increase our success rate, we are currently researching these cells and their supporting environment or niche(see Figure). We are now working on developing artificial corneal stroma, with oral mucosal mesenchymal stem cells as a potential source of cells. We are also involved in the setting up of an Amniotic Membrance bank here at TDC, and in collaborative research with other universities and business enterprises into dry eye and allergies.